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A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase
Protein kinase B (Akt) is a key enzyme in the insulin signalling cascade, required for insulin-stimulated NO production in endothelial cells (ECs). Previous studies have suggested that AMP-activated protein kinase (AMPK) activation stimulates NO synthesis and enhances insulin-stimulated Akt activati...
Autores principales: | Strembitska, Anastasiya, Mancini, Sarah J., Gamwell, Jonathan M., Palmer, Timothy M., Baillie, George S., Salt, Ian P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321332/ https://www.ncbi.nlm.nih.gov/pubmed/30563079 http://dx.doi.org/10.3390/ijms19123886 |
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