HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation

1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) was found to be effective for the Bischler indole synthesis under microwave irradiation in the absence of a metal catalyst. Under the catalysis of HFIP, a wide range of α-amino arylacetones were successfully transformed into indole derivatives with moderate t...

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Autores principales: Yao, Guangkai, Zhang, Zhi-Xiang, Zhang, Cheng-Bei, Xu, Han-Hong, Tang, Ri-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321335/
https://www.ncbi.nlm.nih.gov/pubmed/30558133
http://dx.doi.org/10.3390/molecules23123317
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author Yao, Guangkai
Zhang, Zhi-Xiang
Zhang, Cheng-Bei
Xu, Han-Hong
Tang, Ri-Yuan
author_facet Yao, Guangkai
Zhang, Zhi-Xiang
Zhang, Cheng-Bei
Xu, Han-Hong
Tang, Ri-Yuan
author_sort Yao, Guangkai
collection PubMed
description 1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) was found to be effective for the Bischler indole synthesis under microwave irradiation in the absence of a metal catalyst. Under the catalysis of HFIP, a wide range of α-amino arylacetones were successfully transformed into indole derivatives with moderate to good yields.
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spelling pubmed-63213352019-01-14 HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation Yao, Guangkai Zhang, Zhi-Xiang Zhang, Cheng-Bei Xu, Han-Hong Tang, Ri-Yuan Molecules Article 1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) was found to be effective for the Bischler indole synthesis under microwave irradiation in the absence of a metal catalyst. Under the catalysis of HFIP, a wide range of α-amino arylacetones were successfully transformed into indole derivatives with moderate to good yields. MDPI 2018-12-14 /pmc/articles/PMC6321335/ /pubmed/30558133 http://dx.doi.org/10.3390/molecules23123317 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yao, Guangkai
Zhang, Zhi-Xiang
Zhang, Cheng-Bei
Xu, Han-Hong
Tang, Ri-Yuan
HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation
title HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation
title_full HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation
title_fullStr HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation
title_full_unstemmed HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation
title_short HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation
title_sort hfip-promoted bischler indole synthesis under microwave irradiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321335/
https://www.ncbi.nlm.nih.gov/pubmed/30558133
http://dx.doi.org/10.3390/molecules23123317
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AT zhangchengbei hfippromotedbischlerindolesynthesisundermicrowaveirradiation
AT xuhanhong hfippromotedbischlerindolesynthesisundermicrowaveirradiation
AT tangriyuan hfippromotedbischlerindolesynthesisundermicrowaveirradiation

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