Cargando…

CTCF Expression is Essential for Somatic Cell Viability and Protection Against Cancer

CCCTC-binding factor (CTCF) is a conserved transcription factor that performs diverse roles in transcriptional regulation and chromatin architecture. Cancer genome sequencing reveals diverse acquired mutations in CTCF, which we have shown functions as a tumour suppressor gene. While CTCF is essentia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bailey, Charles G, Metierre, Cynthia, Feng, Yue, Baidya, Kinsha, Filippova, Galina N, Loukinov, Dmitri I, Lobanenkov, Victor V, Semaan, Crystal, Rasko, John EJ
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321389/ https://www.ncbi.nlm.nih.gov/pubmed/30513694 http://dx.doi.org/10.3390/ijms19123832

Ejemplares similares

CTCF binds the proximal exonic region of hTERT and inhibits its transcription
por: Renaud, Stéphanie, et al.
Publicado: (2005)

Loss of Maternal CTCF Is Associated with Peri-Implantation Lethality of Ctcf Null Embryos
por: Moore, James M., et al.
Publicado: (2012)

An updated catalog of CTCF variants associated with neurodevelopmental disorder phenotypes
por: Price, Emma, et al.
Publicado: (2023)

The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis
por: Rivero-Hinojosa, Samuel, et al.
Publicado: (2021)

Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors
por: Renaud, Stéphanie, et al.
Publicado: (2007)

Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions
por: Pugacheva, Elena M., et al.
Publicado: (2015)

Structure–function relationships explain CTCF zinc finger mutation phenotypes in cancer
por: Bailey, Charles G., et al.
Publicado: (2021)

CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention
por: Pugacheva, Elena M., et al.
Publicado: (2020)

Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene
por: Renaud, S., et al.
Publicado: (2007)

Discovering a binary CTCF code with a little help from BORIS
por: Lobanenkov, Victor V., et al.
Publicado: (2017)

CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic
por: Marshall, A D, et al.
Publicado: (2017)

Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner
por: Alharbi, Adel B, et al.
Publicado: (2020)

Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1, both interacting with the TATA binding protein
por: Schwarzenbach, Heidi, et al.
Publicado: (2014)

CTCF as a regulator of alternative splicing: new tricks for an old player
por: Alharbi, Adel B, et al.
Publicado: (2021)

Testis-specific transcriptional regulators selectively occupy BORIS-bound CTCF target regions in mouse male germ cells
por: Rivero-Hinojosa, Samuel, et al.
Publicado: (2017)

BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells
por: Renaud, Stéphanie, et al.
Publicado: (2011)

Corrigendum: Testis-specific transcriptional regulators selectively occupy BORIS-bound CTCF target regions in mouse male germ cells
por: Rivero-Hinojosa, Samuel, et al.
Publicado: (2017)

A Therapeutic Vaccine Targeting Rat BORIS (CTCFL) for the Treatment of Rat Breast Cancer Tumors
por: Loukinov, Dmitri, et al.
Publicado: (2023)

BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours
por: D'Arcy, V, et al.
Publicado: (2008)

BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours
por: D'Arcy, V, et al.
Publicado: (2008)

The downregulation of putative anticancer target BORIS/CTCFL in an addicted myeloid cancer cell line modulates the expression of multiple protein coding and ncRNA genes
por: Teplyakov, Evgeny, et al.
Publicado: (2017)

CTCF is essential for proper mitotic spindle structure and anaphase segregation
por: Chiu, Katherine, et al.
Publicado: (2023)

CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation
por: Fang, He, et al.
Publicado: (2023)

The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo
por: Guan, Fiona H. X., et al.
Publicado: (2017)

Predicting CTCF-mediated chromatin loops using CTCF-MP
por: Zhang, Ruochi, et al.
Publicado: (2018)

CTCF cis-Regulates Trinucleotide Repeat Instability in an Epigenetic Manner: A Novel Basis for Mutational Hot Spot Determination
por: Libby, Randell T., et al.
Publicado: (2008)

The Structural Complexity of the Human BORIS Gene in Gametogenesis and Cancer
por: Pugacheva, Elena M., et al.
Publicado: (2010)

DNA G-Quadruplexes Contribute to CTCF Recruitment
por: Tikhonova, Polina, et al.
Publicado: (2021)

CTCF and cellular heterogeneity
por: Ren, Gang, et al.
Publicado: (2019)

The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation
por: Yang, Fan, et al.
Publicado: (2015)

CTCF: an R/bioconductor data package of human and mouse CTCF binding sites
por: Dozmorov, Mikhail G, et al.
Publicado: (2022)

Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo
por: Tiffen, Jessamy C, et al.
Publicado: (2010)

CTCF: making the right connections
por: Ghirlando, Rodolfo, et al.
Publicado: (2016)

An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis
por: Li, Jiao, et al.
Publicado: (2019)

Identification of chromatin loops from Hi-C interaction matrices by CTCF–CTCF topology classification
por: Galan, Silvia, et al.
Publicado: (2022)

The Fusion of CLEC12A and MIR223HG Arises from a trans-Splicing Event in Normal and Transformed Human Cells
por: Dhungel, Bijay P., et al.
Publicado: (2021)

CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin
por: Ohlsson, Rolf, et al.
Publicado: (2010)

The role of CTCF in regulating nuclear organization
por: Williams, Adam, et al.
Publicado: (2008)

CTCF, Cohesin, and Chromatin in Human Cancer
por: Song, Sang-Hyun, et al.
Publicado: (2017)

Functional roles of CTCF in breast cancer
por: Oh, Sumin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hf139lublfiuao8co6djjqtgvv