Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus
Plant immune activators can protect crops from plant virus pathogens by activating intrinsic immune mechanisms in plants and are widely used in agricultural production. In our previous work, we found that curcumin analogs exhibit excellent biological activity against plant viruses, especially protec...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321402/ https://www.ncbi.nlm.nih.gov/pubmed/30558295 http://dx.doi.org/10.3390/ijms19124065 |
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author | Yin, Limin Gan, Xiuhai Shi, Jing Zan, Ningning Zhang, Awei Ren, Xiaoli Li, Miao Xie, Dandan Hu, Deyu Song, Baoan |
author_facet | Yin, Limin Gan, Xiuhai Shi, Jing Zan, Ningning Zhang, Awei Ren, Xiaoli Li, Miao Xie, Dandan Hu, Deyu Song, Baoan |
author_sort | Yin, Limin |
collection | PubMed |
description | Plant immune activators can protect crops from plant virus pathogens by activating intrinsic immune mechanisms in plants and are widely used in agricultural production. In our previous work, we found that curcumin analogs exhibit excellent biological activity against plant viruses, especially protective activity. Inspired by these results, the active substructure of pentadienone and quinazoline were spliced to obtain curcumin analogs as potential exogenously induced resistant molecule. Bioassay results showed that compound A13 exhibited excellent protective activity for tobacco to against Tobacco mosaic virus (TMV) at 500 μg/mL, with a value of 70.4 ± 2.6% compared with control treatments, which was better than that of the plant immune activator chitosan oligosaccharide (49.0 ± 5.9%). The protective activity is due to compound A13 inducing tobacco resistance to TMV, which was related to defense-related enzymes, defense-related genes, and photosynthesis. This was confirmed by the up-regulated expression of proteins that mediate stress responses and oxidative phosphorylation. |
format | Online Article Text |
id | pubmed-6321402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63214022019-01-07 Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus Yin, Limin Gan, Xiuhai Shi, Jing Zan, Ningning Zhang, Awei Ren, Xiaoli Li, Miao Xie, Dandan Hu, Deyu Song, Baoan Int J Mol Sci Article Plant immune activators can protect crops from plant virus pathogens by activating intrinsic immune mechanisms in plants and are widely used in agricultural production. In our previous work, we found that curcumin analogs exhibit excellent biological activity against plant viruses, especially protective activity. Inspired by these results, the active substructure of pentadienone and quinazoline were spliced to obtain curcumin analogs as potential exogenously induced resistant molecule. Bioassay results showed that compound A13 exhibited excellent protective activity for tobacco to against Tobacco mosaic virus (TMV) at 500 μg/mL, with a value of 70.4 ± 2.6% compared with control treatments, which was better than that of the plant immune activator chitosan oligosaccharide (49.0 ± 5.9%). The protective activity is due to compound A13 inducing tobacco resistance to TMV, which was related to defense-related enzymes, defense-related genes, and photosynthesis. This was confirmed by the up-regulated expression of proteins that mediate stress responses and oxidative phosphorylation. MDPI 2018-12-15 /pmc/articles/PMC6321402/ /pubmed/30558295 http://dx.doi.org/10.3390/ijms19124065 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yin, Limin Gan, Xiuhai Shi, Jing Zan, Ningning Zhang, Awei Ren, Xiaoli Li, Miao Xie, Dandan Hu, Deyu Song, Baoan Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus |
title | Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus |
title_full | Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus |
title_fullStr | Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus |
title_full_unstemmed | Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus |
title_short | Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus |
title_sort | induced resistance mechanism of novel curcumin analogs bearing a quinazoline moiety to plant virus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321402/ https://www.ncbi.nlm.nih.gov/pubmed/30558295 http://dx.doi.org/10.3390/ijms19124065 |
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