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The Role of Combined Penetration Enhancers in Nasal Microspheres on In Vivo Drug Bioavailability
Microspheres based on both methyl-β-cyclodextrins and chitosan were prepared by spray-drying as nasal formulations of a model polar drug to analyze, firstly, how the composition of the carrier affects drug permeation across synthetic membranes and, secondly, how it induces systemic or brain delivery...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321492/ https://www.ncbi.nlm.nih.gov/pubmed/30373187 http://dx.doi.org/10.3390/pharmaceutics10040206 |