Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors

A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), two enzymes responsible for the hydrol...

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Detalles Bibliográficos
Autores principales: Green, Keith D., Fosso, Marina Y., Garneau-Tsodikova, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321525/
https://www.ncbi.nlm.nih.gov/pubmed/30544832
http://dx.doi.org/10.3390/molecules23123252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321525/
https://www.ncbi.nlm.nih.gov/pubmed/30544832
http://dx.doi.org/10.3390/molecules23123252

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