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Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors

A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), two enzymes responsible for the hydrol...

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Detalles Bibliográficos
Autores principales:	Green, Keith D., Fosso, Marina Y., Garneau-Tsodikova, Sylvie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321525/ https://www.ncbi.nlm.nih.gov/pubmed/30544832 http://dx.doi.org/10.3390/molecules23123252

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