Synthesis, Biological Evaluation and Low-Toxic Formulation Development of Glycosylated Paclitaxel Prodrugs

Paclitaxel (PTX) is a famous anti-cancer drug with poor aqueous solubility. In clinical practices, Cremophor EL (polyethoxylated castor oil), a toxic surfactant, is used for dissolution of PTX, which accounts for serious side effects. In the present study, a single glucose-conjugated PTX prodrug (SG...

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Detalles Bibliográficos
Autores principales: Mao, Yukang, Zhang, Yili, Luo, Zheng, Zhan, Ruoting, Xu, Hui, Chen, Weiwen, Huang, Huicai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321537/
https://www.ncbi.nlm.nih.gov/pubmed/30563132
http://dx.doi.org/10.3390/molecules23123211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321537/
https://www.ncbi.nlm.nih.gov/pubmed/30563132
http://dx.doi.org/10.3390/molecules23123211

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