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Synthesis, Biological Evaluation and Low-Toxic Formulation Development of Glycosylated Paclitaxel Prodrugs

Paclitaxel (PTX) is a famous anti-cancer drug with poor aqueous solubility. In clinical practices, Cremophor EL (polyethoxylated castor oil), a toxic surfactant, is used for dissolution of PTX, which accounts for serious side effects. In the present study, a single glucose-conjugated PTX prodrug (SG...

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Detalles Bibliográficos
Autores principales:	Mao, Yukang, Zhang, Yili, Luo, Zheng, Zhan, Ruoting, Xu, Hui, Chen, Weiwen, Huang, Huicai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321537/ https://www.ncbi.nlm.nih.gov/pubmed/30563132 http://dx.doi.org/10.3390/molecules23123211

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