Construction of Highly Stable Cytotoxic Nuclear-Directed Ribonucleases

Ribonucleases are proteins whose use is promising in anticancer therapy. We have previously constructed different human pancreatic ribonuclease variants that are selectively cytotoxic for tumor cells by introducing a nuclear localization signal into their sequence. However, these modifications produ...

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Detalles Bibliográficos
Autores principales: Roura Padrosa, David, Castro, Jessica, Romero-Casañas, Alejandro, Ribó, Marc, Vilanova, Maria, Benito, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321540/
https://www.ncbi.nlm.nih.gov/pubmed/30544927
http://dx.doi.org/10.3390/molecules23123273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321540/
https://www.ncbi.nlm.nih.gov/pubmed/30544927
http://dx.doi.org/10.3390/molecules23123273

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