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Construction of Highly Stable Cytotoxic Nuclear-Directed Ribonucleases
Ribonucleases are proteins whose use is promising in anticancer therapy. We have previously constructed different human pancreatic ribonuclease variants that are selectively cytotoxic for tumor cells by introducing a nuclear localization signal into their sequence. However, these modifications produ...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321540/ https://www.ncbi.nlm.nih.gov/pubmed/30544927 http://dx.doi.org/10.3390/molecules23123273 |