Cargando…

Iso-α-Acids, the Bitter Components of Beer, Suppress Microglial Inflammation in rTg4510 Tauopathy

Due to the growth in aging populations, prevention for cognitive decline and dementia are in great demand. We previously demonstrated that the consumption of iso-α-acids (IAA), the hop-derived bitter compounds in beer, prevents inflammation and Alzheimer’s disease pathology in model mice. However, t...

Descripción completa

Detalles Bibliográficos
Autores principales: Ano, Yasuhisa, Takaichi, Yuta, Uchida, Kazuyuki, Kondo, Keiji, Nakayama, Hiroyuki, Takashima, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321553/
https://www.ncbi.nlm.nih.gov/pubmed/30501069
http://dx.doi.org/10.3390/molecules23123133
_version_ 1783385470044995584
author Ano, Yasuhisa
Takaichi, Yuta
Uchida, Kazuyuki
Kondo, Keiji
Nakayama, Hiroyuki
Takashima, Akihiko
author_facet Ano, Yasuhisa
Takaichi, Yuta
Uchida, Kazuyuki
Kondo, Keiji
Nakayama, Hiroyuki
Takashima, Akihiko
author_sort Ano, Yasuhisa
collection PubMed
description Due to the growth in aging populations, prevention for cognitive decline and dementia are in great demand. We previously demonstrated that the consumption of iso-α-acids (IAA), the hop-derived bitter compounds in beer, prevents inflammation and Alzheimer’s disease pathology in model mice. However, the effects of iso-α-acids on inflammation induced by other agents aside from amyloid β have not been investigated. In this study, we demonstrated that the consumption of iso-α-acids suppressed microglial inflammation in the frontal cortex of rTg4510 tauopathy mice. In addition, the levels of inflammatory cytokines and chemokines, including IL-1β and MIP-1β, in the frontal cortex of rTg4510 mice were greater than those of wild-type mice, and were reduced in rTg4510 mice fed with iso-α-acids. Flow cytometry analysis demonstrated that the expression of cells producing CD86, CD68, TSPO, MIP-1α, TNF-α, and IL-1β in microglia was increased in rTg4510 mice compared with wild-type mice. Furthermore, the expression of CD86- and MIP-1α-producing cells was reduced in rTg4510 mice administered with iso-α-acids. Moreover, the consumption of iso-α-acids reduced the levels of phosphorylated tau in the frontal cortex. Collectively, these results suggest that the consumption of iso-α-acids prevents the inflammation induced in tauopathy mice. Thus, iso-α-acids may help in preventing inflammation-related brain disorders.
format Online
Article
Text
id pubmed-6321553
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63215532019-01-14 Iso-α-Acids, the Bitter Components of Beer, Suppress Microglial Inflammation in rTg4510 Tauopathy Ano, Yasuhisa Takaichi, Yuta Uchida, Kazuyuki Kondo, Keiji Nakayama, Hiroyuki Takashima, Akihiko Molecules Article Due to the growth in aging populations, prevention for cognitive decline and dementia are in great demand. We previously demonstrated that the consumption of iso-α-acids (IAA), the hop-derived bitter compounds in beer, prevents inflammation and Alzheimer’s disease pathology in model mice. However, the effects of iso-α-acids on inflammation induced by other agents aside from amyloid β have not been investigated. In this study, we demonstrated that the consumption of iso-α-acids suppressed microglial inflammation in the frontal cortex of rTg4510 tauopathy mice. In addition, the levels of inflammatory cytokines and chemokines, including IL-1β and MIP-1β, in the frontal cortex of rTg4510 mice were greater than those of wild-type mice, and were reduced in rTg4510 mice fed with iso-α-acids. Flow cytometry analysis demonstrated that the expression of cells producing CD86, CD68, TSPO, MIP-1α, TNF-α, and IL-1β in microglia was increased in rTg4510 mice compared with wild-type mice. Furthermore, the expression of CD86- and MIP-1α-producing cells was reduced in rTg4510 mice administered with iso-α-acids. Moreover, the consumption of iso-α-acids reduced the levels of phosphorylated tau in the frontal cortex. Collectively, these results suggest that the consumption of iso-α-acids prevents the inflammation induced in tauopathy mice. Thus, iso-α-acids may help in preventing inflammation-related brain disorders. MDPI 2018-11-29 /pmc/articles/PMC6321553/ /pubmed/30501069 http://dx.doi.org/10.3390/molecules23123133 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ano, Yasuhisa
Takaichi, Yuta
Uchida, Kazuyuki
Kondo, Keiji
Nakayama, Hiroyuki
Takashima, Akihiko
Iso-α-Acids, the Bitter Components of Beer, Suppress Microglial Inflammation in rTg4510 Tauopathy
title Iso-α-Acids, the Bitter Components of Beer, Suppress Microglial Inflammation in rTg4510 Tauopathy
title_full Iso-α-Acids, the Bitter Components of Beer, Suppress Microglial Inflammation in rTg4510 Tauopathy
title_fullStr Iso-α-Acids, the Bitter Components of Beer, Suppress Microglial Inflammation in rTg4510 Tauopathy
title_full_unstemmed Iso-α-Acids, the Bitter Components of Beer, Suppress Microglial Inflammation in rTg4510 Tauopathy
title_short Iso-α-Acids, the Bitter Components of Beer, Suppress Microglial Inflammation in rTg4510 Tauopathy
title_sort iso-α-acids, the bitter components of beer, suppress microglial inflammation in rtg4510 tauopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321553/
https://www.ncbi.nlm.nih.gov/pubmed/30501069
http://dx.doi.org/10.3390/molecules23123133
work_keys_str_mv AT anoyasuhisa isoaacidsthebittercomponentsofbeersuppressmicroglialinflammationinrtg4510tauopathy
AT takaichiyuta isoaacidsthebittercomponentsofbeersuppressmicroglialinflammationinrtg4510tauopathy
AT uchidakazuyuki isoaacidsthebittercomponentsofbeersuppressmicroglialinflammationinrtg4510tauopathy
AT kondokeiji isoaacidsthebittercomponentsofbeersuppressmicroglialinflammationinrtg4510tauopathy
AT nakayamahiroyuki isoaacidsthebittercomponentsofbeersuppressmicroglialinflammationinrtg4510tauopathy
AT takashimaakihiko isoaacidsthebittercomponentsofbeersuppressmicroglialinflammationinrtg4510tauopathy