Semisynthesis and Inhibitory Effects of Solidagenone Derivatives on TLR-Mediated Inflammatory Responses

A series of nine derivatives (2–10) were prepared from the diterpene solidagenone (1) and their structures were elucidated by means of spectroscopic studies. Their ability to inhibit inflammatory responses elicited in peritoneal macrophages by TLR ligands was investigated. Compounds 5 and 6 showed s...

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Detalles Bibliográficos
Autores principales: Cuadrado, Irene, Amesty, Ángel, Cedrón, Juan Carlos, Oberti, Juan Carlos, Estévez-Braun, Ana, Hortelano, Sonsoles, de las Heras, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321690/
https://www.ncbi.nlm.nih.gov/pubmed/30518153
http://dx.doi.org/10.3390/molecules23123197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321690/
https://www.ncbi.nlm.nih.gov/pubmed/30518153
http://dx.doi.org/10.3390/molecules23123197

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