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In vitro evaluation of the activity of an essential oil from Pistacia vera L. variety Bronte hull against Candida sp.
BACKGROUND: Candida sp. represent the most common cause of fungal infections worldwide. In the present work, we have evaluated the activity of an essential oil extracted from pistachio hulls against a number of standard and clinical strains of Candida sp. METHODS: C. albicans ATCC 64550, C. parapsil...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322278/ https://www.ncbi.nlm.nih.gov/pubmed/30612544 http://dx.doi.org/10.1186/s12906-018-2425-0 |
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author | D’Arrigo, Manuela Bisignano, Carlo Irrera, Pierangela Smeriglio, Antonella Zagami, Roberto Trombetta, Domenico Romeo, Orazio Mandalari, Giuseppina |
author_facet | D’Arrigo, Manuela Bisignano, Carlo Irrera, Pierangela Smeriglio, Antonella Zagami, Roberto Trombetta, Domenico Romeo, Orazio Mandalari, Giuseppina |
author_sort | D’Arrigo, Manuela |
collection | PubMed |
description | BACKGROUND: Candida sp. represent the most common cause of fungal infections worldwide. In the present work, we have evaluated the activity of an essential oil extracted from pistachio hulls against a number of standard and clinical strains of Candida sp. METHODS: C. albicans ATCC 64550, C. parapsilosis ATCC 22019, 4 clinical strains of C. albicans, 3 clinical strains of C. parapsilosis and 3 clinical strains of C. glabrata were used. All clinical isolates were identified by species-specific PCR-based methods. Susceptibility studies were performed using pistachio hull essential oil alone or in combination with antifungal compounds. The interactions between pistachio hull essential oil and selected antifungal compounds were also evaluated using the checkerboard method and the mechanisms of interaction investigated by droplet size distribution. RESULTS: Pistachio hull essential oil was fungicidal at the concentrations between 2.50 and 5.0 mg/ml. D-limonene and 3-Carene were the components with major activity. An antagonistic effect was observed with all combinations tested. CONCLUSION: The antifungal activity of pistachio hull essential oil could be used to help control resistance in Candida species. More studies need to be performed to elucidate the mechanisms responsible for the activity of pistachio hull essential oil. |
format | Online Article Text |
id | pubmed-6322278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63222782019-01-09 In vitro evaluation of the activity of an essential oil from Pistacia vera L. variety Bronte hull against Candida sp. D’Arrigo, Manuela Bisignano, Carlo Irrera, Pierangela Smeriglio, Antonella Zagami, Roberto Trombetta, Domenico Romeo, Orazio Mandalari, Giuseppina BMC Complement Altern Med Research Article BACKGROUND: Candida sp. represent the most common cause of fungal infections worldwide. In the present work, we have evaluated the activity of an essential oil extracted from pistachio hulls against a number of standard and clinical strains of Candida sp. METHODS: C. albicans ATCC 64550, C. parapsilosis ATCC 22019, 4 clinical strains of C. albicans, 3 clinical strains of C. parapsilosis and 3 clinical strains of C. glabrata were used. All clinical isolates were identified by species-specific PCR-based methods. Susceptibility studies were performed using pistachio hull essential oil alone or in combination with antifungal compounds. The interactions between pistachio hull essential oil and selected antifungal compounds were also evaluated using the checkerboard method and the mechanisms of interaction investigated by droplet size distribution. RESULTS: Pistachio hull essential oil was fungicidal at the concentrations between 2.50 and 5.0 mg/ml. D-limonene and 3-Carene were the components with major activity. An antagonistic effect was observed with all combinations tested. CONCLUSION: The antifungal activity of pistachio hull essential oil could be used to help control resistance in Candida species. More studies need to be performed to elucidate the mechanisms responsible for the activity of pistachio hull essential oil. BioMed Central 2019-01-07 /pmc/articles/PMC6322278/ /pubmed/30612544 http://dx.doi.org/10.1186/s12906-018-2425-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article D’Arrigo, Manuela Bisignano, Carlo Irrera, Pierangela Smeriglio, Antonella Zagami, Roberto Trombetta, Domenico Romeo, Orazio Mandalari, Giuseppina In vitro evaluation of the activity of an essential oil from Pistacia vera L. variety Bronte hull against Candida sp. |
title | In vitro evaluation of the activity of an essential oil from Pistacia vera L. variety Bronte hull against Candida sp. |
title_full | In vitro evaluation of the activity of an essential oil from Pistacia vera L. variety Bronte hull against Candida sp. |
title_fullStr | In vitro evaluation of the activity of an essential oil from Pistacia vera L. variety Bronte hull against Candida sp. |
title_full_unstemmed | In vitro evaluation of the activity of an essential oil from Pistacia vera L. variety Bronte hull against Candida sp. |
title_short | In vitro evaluation of the activity of an essential oil from Pistacia vera L. variety Bronte hull against Candida sp. |
title_sort | in vitro evaluation of the activity of an essential oil from pistacia vera l. variety bronte hull against candida sp. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322278/ https://www.ncbi.nlm.nih.gov/pubmed/30612544 http://dx.doi.org/10.1186/s12906-018-2425-0 |
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