Efficient and precise editing of endogenous transcripts with SNAP-tagged ADARs

Molecular tools to target RNA site-specifically allow recoding of RNA information and processing. SNAP-tagged deaminases, guided by a chemically stabilized guideRNA, enable the simultaneous editing of targeted adenosine to inosine in several endogenous transcripts, with high efficiency (up to 90%),...

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Detalles Bibliográficos
Autores principales: Vogel, Paul, Moschref, Matin, Li, Qin, Merkle, Tobias, Selvasaravanan, Karthika D., Li, Jin Billy, Stafforst, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322650/
https://www.ncbi.nlm.nih.gov/pubmed/29967493
http://dx.doi.org/10.1038/s41592-018-0017-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322650/
https://www.ncbi.nlm.nih.gov/pubmed/29967493
http://dx.doi.org/10.1038/s41592-018-0017-z

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