Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution

BACKGROUND: Idarucizumab is a humanized Fab fragment that specifically reverses dabigatran anticoagulation. In trauma, volume expanders are used for resuscitation to compensate for blood loss and hemorrhagic shock, but it is unknown whether volume expanders influence the binding of dabigatran to its...

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Detalles Bibliográficos
Autores principales: Grottke, Oliver, van Ryn, Joanne, Zentai, Christian, Gan, Guanfa, Honickel, Markus, Rossaint, Rolf, ten Cate, Hugo, Spronk, Henri M. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322768/
https://www.ncbi.nlm.nih.gov/pubmed/30615630
http://dx.doi.org/10.1371/journal.pone.0209350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322768/
https://www.ncbi.nlm.nih.gov/pubmed/30615630
http://dx.doi.org/10.1371/journal.pone.0209350

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