Fate of the Fc fusion protein aflibercept in retinal endothelial cells: competition of recycling and degradation

PURPOSE: Intravitreal injection of the VEGF-binding protein aflibercept is widely used to treat various ocular diseases. In vitro, immortalized bovine retinal endothelial cells (iBREC) take up and transport aflibercept through the cell layer in a serum-dependent manner, likely mediated through the n...

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Detalles Bibliográficos
Autores principales: Deissler, Heidrun L., Lang, Gerhard K., Lang, Gabriele E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323079/
https://www.ncbi.nlm.nih.gov/pubmed/30367290
http://dx.doi.org/10.1007/s00417-018-4166-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323079/
https://www.ncbi.nlm.nih.gov/pubmed/30367290
http://dx.doi.org/10.1007/s00417-018-4166-7

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