Cargando…
The transcriptome landscape of the carcinogenic treatment response in the blind mole rat: insights into cancer resistance mechanisms
BACKGROUND: Spalax, the blind mole rat, developed an extraordinary cancer resistance during 40 million years of evolution in a subterranean, hypoxic, thus DNA damaging, habitat. In 50 years of Spalax research, no spontaneous cancer development has been observed. The mechanisms underlying this resist...
Autores principales: | Altwasser, Robert, Paz, Arnon, Korol, Abraham, Manov, Irena, Avivi, Aaron, Shams, Imad |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323709/ https://www.ncbi.nlm.nih.gov/pubmed/30621584 http://dx.doi.org/10.1186/s12864-018-5417-z |
Ejemplares similares
-
Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax
por: Domankevich, Vered, et al.
Publicado: (2016) -
Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence
por: Manov, Irena, et al.
Publicado: (2013) -
Senescent Secretome of Blind Mole Rat Spalax Inhibits Malignant Behavior of Human Breast Cancer Cells Triggering Bystander Senescence and Targeting Inflammatory Response
por: Odeh, Amani, et al.
Publicado: (2023) -
Genome maintenance and bioenergetics of the long-lived hypoxia-tolerant and cancer-resistant blind mole rat, Spalax: a cross-species analysis of brain transcriptome
por: Malik, Assaf, et al.
Publicado: (2016) -
Transcriptome Sequencing of the Blind Subterranean Mole Rat, Spalax galili: Utility and Potential for the Discovery of Novel Evolutionary Patterns
por: Malik, Assaf, et al.
Publicado: (2011)