Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock: The Rapid Administration of Carnitine in Sepsis (RACE) Randomized Clinical Trial

IMPORTANCE: Sepsis induces profound metabolic derangements, while exogenous levocarnitine mitigates metabolic dysfunction by enhancing glucose and lactate oxidation and increasing fatty acid shuttling. Previous trials in sepsis suggest beneficial effects of levocarnitine on patient-centered outcomes...

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Detalles Bibliográficos
Autores principales: Jones, Alan E., Puskarich, Michael A., Shapiro, Nathan I., Guirgis, Faheem W., Runyon, Michael, Adams, Jason Y., Sherwin, Robert, Arnold, Ryan, Roberts, Brian W., Kurz, Michael C., Wang, Henry E., Kline, Jeffrey A., Courtney, D. Mark, Trzeciak, Stephen, Sterling, Sarah A., Nandi, Utsav, Patki, Deepti, Viele, Kert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2018
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324339/
https://www.ncbi.nlm.nih.gov/pubmed/30646314
http://dx.doi.org/10.1001/jamanetworkopen.2018.6076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324339/
https://www.ncbi.nlm.nih.gov/pubmed/30646314
http://dx.doi.org/10.1001/jamanetworkopen.2018.6076

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