Design, Synthesis, and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein–Coupled Receptors

Chemoproteomic approaches to identify ligand-receptor interactions have gained popularity. However, identifying transmembrane receptors remains challenging. A new trifunctional probe to aid the nonbiased identification of such receptors was developed and synthesized using a convenient seven-step syn...

Descripción completa

Detalles Bibliográficos
Autores principales: Müskens, Frederike M., Ward, Richard J., Herkt, Dominik, van de Langemheen, Helmus, Tobin, Andrew B., Liskamp, Rob M. J., Milligan, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324650/
https://www.ncbi.nlm.nih.gov/pubmed/30514721
http://dx.doi.org/10.1124/mol.118.114249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324650/
https://www.ncbi.nlm.nih.gov/pubmed/30514721
http://dx.doi.org/10.1124/mol.118.114249

Ejemplares similares