Cargando…

In vivo assembly and large-scale purification of a GPCR - Gα fusion with Gβγ, and characterization of the active complex

G protein coupled receptors (GPCRs) are central players in recognizing a variety of stimuli to mediate diverse cellular responses. This myriad of functions is accomplished by their modular interactions with downstream intracellular transducers, such as heterotrimeric G proteins and arrestins. Assemb...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Abhinav, Plückthun, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324789/
https://www.ncbi.nlm.nih.gov/pubmed/30620756
http://dx.doi.org/10.1371/journal.pone.0210131