Ligand-activated PPARδ inhibits angiotensin II-stimulated hypertrophy of vascular smooth muscle cells by targeting ROS

We investigated the effect of peroxisome proliferator-activated receptor δ (PPARδ) on angiotensin II (Ang II)-triggered hypertrophy of vascular smooth muscle cells (VSMCs). Activation of PPARδ by GW501516, a specific ligand of PPARδ, significantly inhibited Ang II-stimulated protein synthesis in a c...

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Detalles Bibliográficos
Autores principales: Kang, Eun Sil, Hwang, Jung Seok, Lee, Won Jin, Lee, Gyeong Hee, Choi, Mi-Jung, Paek, Kyung Shin, Lim, Dae-Seog, Seo, Han Geuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324793/
https://www.ncbi.nlm.nih.gov/pubmed/30620754
http://dx.doi.org/10.1371/journal.pone.0210482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324793/
https://www.ncbi.nlm.nih.gov/pubmed/30620754
http://dx.doi.org/10.1371/journal.pone.0210482

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