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Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence

Mitochondrial dynamics are tightly controlled by fusion and fission, and their dysregulation and excess reactive oxygen species (ROS) contribute to endothelial cell (EC) dysfunction. How redox signals regulate coupling between mitochondrial dynamics and endothelial (dys)function remains unknown. Her...

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Detalles Bibliográficos
Autores principales: Kim, Young-Mee, Youn, Seock-Won, Sudhahar, Varadarajan, Das, Archita, Chandhri, Reyhaan, Grajal, Henar Cuervo, Kweon, Junghun, Leanhart, Silvia, He, Lianying, Toth, Peter T., Kitajewski, Jan, Rehman, Jalees, Yoon, Yisang, Cho, Jaehyung, Fukai, Tohru, Ushio-Fukai, Masuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324937/
https://www.ncbi.nlm.nih.gov/pubmed/29924999
http://dx.doi.org/10.1016/j.celrep.2018.05.054