Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation

The extension of the amyloid hypothesis to include non-protein metabolite assemblies invokes a paradigm for the pathology of inborn error of metabolism disorders. However, a direct demonstration of the assembly of metabolite amyloid-like structures has so far been provided only in vitro. Here, we es...

Descripción completa

Detalles Bibliográficos
Autores principales: Laor, Dana, Sade, Dorin, Shaham-Niv, Shira, Zaguri, Dor, Gartner, Myra, Basavalingappa, Vasantha, Raveh, Avi, Pichinuk, Edward, Engel, Hamutal, Iwasaki, Keita, Yamamoto, Tatsuyuki, Noothalapati, Hemanth, Gazit, Ehud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325136/
https://www.ncbi.nlm.nih.gov/pubmed/30622276
http://dx.doi.org/10.1038/s41467-018-07966-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325136/
https://www.ncbi.nlm.nih.gov/pubmed/30622276
http://dx.doi.org/10.1038/s41467-018-07966-5

Ejemplares similares