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Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
The extension of the amyloid hypothesis to include non-protein metabolite assemblies invokes a paradigm for the pathology of inborn error of metabolism disorders. However, a direct demonstration of the assembly of metabolite amyloid-like structures has so far been provided only in vitro. Here, we es...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325136/ https://www.ncbi.nlm.nih.gov/pubmed/30622276 http://dx.doi.org/10.1038/s41467-018-07966-5 |