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Blockade of CTLA-4 and Tim-3 pathways induces fetal loss with altered cytokine profiles by decidual CD4(+)T cells

The single and/or combination use of immune checkpoint blockade therapies in human infectious diseases and cancer are rapidly expanding. Despite early efforts, substantial uncertainty remains about the safety and efficacy of immune checkpoint blockade in some populations. Cytotoxic T-lymphocyte-asso...

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Detalles Bibliográficos
Autores principales: Wang, Songcun, Chen, Chunqin, Li, Mengdie, Qian, Jinfeng, Sun, Fengyun, Li, Yunyun, Yu, Min, Wang, Mingyan, Zang, Xingxing, Zhu, Rui, Li, Dajin, Du, Meirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325160/
https://www.ncbi.nlm.nih.gov/pubmed/30622243
http://dx.doi.org/10.1038/s41419-018-1251-0