Enhancing GABAergic Transmission Improves Locomotion in a Caenorhabditis elegans Model of Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by degeneration of spinal motor neurons resulting in variable degrees of muscular wasting and weakness. It is caused by a loss-of-function mutation in the survival motor neuron (SMN1) gene. Caenorhabditis elegans mutants lacking...

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Detalles Bibliográficos
Autores principales: Wu, Chia-Yen, Gagnon, David A., Sardin, Juliette S., Barot, Urva, Telenson, Alex, Arratia, Paulo E., Kalb, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325564/
https://www.ncbi.nlm.nih.gov/pubmed/30627660
http://dx.doi.org/10.1523/ENEURO.0289-18.2018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325564/
https://www.ncbi.nlm.nih.gov/pubmed/30627660
http://dx.doi.org/10.1523/ENEURO.0289-18.2018

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