The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis

Treatments to stop gray matter degeneration are needed to prevent progressive disability in multiple sclerosis (MS). We tested whether inhibiting mixed-lineage kinases (MLKs), which can drive inflammatory microglial activation and neuronal degeneration, could protect hippocampal synapses in C57BL/6...

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Detalles Bibliográficos
Autores principales: Bellizzi, Matthew J., Hammond, Jennetta W., Li, Herman, Gantz Marker, Mary A., Marker, Daniel F., Freeman, Robert S., Gelbard, Harris A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325567/
https://www.ncbi.nlm.nih.gov/pubmed/30627663
http://dx.doi.org/10.1523/ENEURO.0245-18.2018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325567/
https://www.ncbi.nlm.nih.gov/pubmed/30627663
http://dx.doi.org/10.1523/ENEURO.0245-18.2018

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