Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero

The mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in cell metabolism, growth, and proliferation. The overactivation of mTOR has been implicated in the pathogenesis of syndromic autism spectrum disorder (ASD), such as tuberous sclerosis complex (TSC). Treatment with the...

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Detalles Bibliográficos
Autores principales: Kotajima-Murakami, Hiroko, Kobayashi, Toshiyuki, Kashii, Hirofumi, Sato, Atsushi, Hagino, Yoko, Tanaka, Miho, Nishito, Yasumasa, Takamatsu, Yukio, Uchino, Shigeo, Ikeda, Kazutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325753/
https://www.ncbi.nlm.nih.gov/pubmed/30621732
http://dx.doi.org/10.1186/s13041-018-0423-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325753/
https://www.ncbi.nlm.nih.gov/pubmed/30621732
http://dx.doi.org/10.1186/s13041-018-0423-2

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