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Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction

BACKGROUND: In heart failure the myocardium becomes insulin resistant which negatively influences cardiac energy metabolism and function, while increasing cardiac insulin signalling improves cardiac function and prevents adverse remodelling in the failing heart. Glucagon’s action on cardiac glucose...

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Detalles Bibliográficos
Autores principales: Karwi, Qutuba G., Zhang, Liyan, Wagg, Cory S., Wang, Wang, Ghandi, Manoj, Thai, Dung, Yan, Hai, Ussher, John R., Oudit, Gavin Y., Lopaschuk, Gary D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325856/
https://www.ncbi.nlm.nih.gov/pubmed/30626440
http://dx.doi.org/10.1186/s12933-019-0806-4