Fine-Scale Resolution of Runs of Homozygosity Reveal Patterns of Inbreeding and Substantial Overlap with Recessive Disease Genotypes in Domestic Dogs

Inbreeding leaves distinct genomic traces, most notably long genomic tracts that are identical by descent and completely homozygous. These runs of homozygosity (ROH) can contribute to inbreeding depression if they contain deleterious variants that are fully or partially recessive. Several lines of e...

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Detalles Bibliográficos
Autores principales: Sams, Aaron J., Boyko, Adam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2018
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325901/
https://www.ncbi.nlm.nih.gov/pubmed/30429214
http://dx.doi.org/10.1534/g3.118.200836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325901/
https://www.ncbi.nlm.nih.gov/pubmed/30429214
http://dx.doi.org/10.1534/g3.118.200836

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