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Asymmetric synthesis of (–)-naltrexone
(–)-Naltrexone, an opioid antagonist used extensively for the management of drug abuse, is derived from naturally occurring opioids. Herein, we report the first asymmetric synthesis of (–)-naltrexone that does not proceed through thebaine. The synthesis starts with simple, achiral precursors with ca...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326069/ https://www.ncbi.nlm.nih.gov/pubmed/30713650 http://dx.doi.org/10.1039/c8sc03748e |