Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung

Endoplasmic reticulum stress (ER stress) has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease of progressive fibrosis and respiratory failure. ER stress activates a signaling pathway called the unfolded protein response (UPR) that either restores homeostasis or p...

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Detalles Bibliográficos
Autores principales: Thamsen, Maike, Ghosh, Rajarshi, Auyeung, Vincent C., Brumwell, Alexis, Chapman, Harold A., Backes, Bradley J., Perara, Gayani, Maly, Dustin J., Sheppard, Dean, Papa, Feroz R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326459/
https://www.ncbi.nlm.nih.gov/pubmed/30625178
http://dx.doi.org/10.1371/journal.pone.0209824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326459/
https://www.ncbi.nlm.nih.gov/pubmed/30625178
http://dx.doi.org/10.1371/journal.pone.0209824

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