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Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung
Endoplasmic reticulum stress (ER stress) has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease of progressive fibrosis and respiratory failure. ER stress activates a signaling pathway called the unfolded protein response (UPR) that either restores homeostasis or p...
Autores principales: | Thamsen, Maike, Ghosh, Rajarshi, Auyeung, Vincent C., Brumwell, Alexis, Chapman, Harold A., Backes, Bradley J., Perara, Gayani, Maly, Dustin J., Sheppard, Dean, Papa, Feroz R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326459/ https://www.ncbi.nlm.nih.gov/pubmed/30625178 http://dx.doi.org/10.1371/journal.pone.0209824 |
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