Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation

[Image: see text] We have recently shown that 2-aminoimidazole is a superior nucleotide activating group for nonenzymatic RNA copying. Here we describe a prebiotic synthesis of 2-aminoimidazole that shares a common mechanistic pathway with that of 2-aminooxazole, a previously described key intermedi...

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Detalles Bibliográficos
Autores principales: Fahrenbach, Albert C., Giurgiu, Constantin, Tam, Chun Pong, Li, Li, Hongo, Yayoi, Aono, Masashi, Szostak, Jack W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326526/
https://www.ncbi.nlm.nih.gov/pubmed/28640999
http://dx.doi.org/10.1021/jacs.7b01562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326526/
https://www.ncbi.nlm.nih.gov/pubmed/28640999
http://dx.doi.org/10.1021/jacs.7b01562

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