Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide

[Image: see text] Nonenzymatic RNA primer extension by activated mononucleotides has long served as a model for the study of prebiotic RNA copying. We have recently shown that the rate of primer extension is greatly enhanced by the formation of an imidazolium-bridged dinucleotide between the incomin...

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Detalles Bibliográficos
Autores principales: Zhang, Wen, Tam, Chun Pong, Zhou, Lijun, Oh, Seung Soo, Wang, Jiawei, Szostak, Jack W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326529/
https://www.ncbi.nlm.nih.gov/pubmed/29411978
http://dx.doi.org/10.1021/jacs.7b11750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326529/
https://www.ncbi.nlm.nih.gov/pubmed/29411978
http://dx.doi.org/10.1021/jacs.7b11750

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