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Comparison between continuous and discrete doses for model based designs in cancer dose finding
Despite of an extensive statistical literature showing that discretizing continuous variables results in substantial loss of information, categorization of continuous variables has been a common practice in clinical research and in cancer dose finding (phase I) clinical trials. The objective of this...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326565/ https://www.ncbi.nlm.nih.gov/pubmed/30625194 http://dx.doi.org/10.1371/journal.pone.0210139 |