The ER-alpha mutation Y537S confers Tamoxifen-resistance via enhanced mitochondrial metabolism, glycolysis and Rho-GDI/PTEN signaling: Implicating TIGAR in somatic resistance to endocrine therapy

Naturally-occurring somatic mutations in the estrogen receptor gene (ESR1) have been previously implicated in the clinical development of resistance to hormonal therapies, such as Tamoxifen. For example, the somatic mutation Y537S has been specifically associated with acquired endocrine resistance....

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Detalles Bibliográficos
Autores principales: Fiorillo, Marco, Sanchez-Alvarez, Rosa, Sotgia, Federica, Lisanti, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326696/
https://www.ncbi.nlm.nih.gov/pubmed/30573703
http://dx.doi.org/10.18632/aging.101690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326696/
https://www.ncbi.nlm.nih.gov/pubmed/30573703
http://dx.doi.org/10.18632/aging.101690

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