Alu insertion variants alter mRNA splicing

RNA splicing is a highly regulated process dependent on sequences near splice sites. Insertions of Alu retrotransposons can disrupt splice sites or bind splicing regulators. We hypothesized that some common inherited polymorphic Alu insertions are responsible for splicing QTLs (sQTL). We focused on...

Descripción completa

Detalles Bibliográficos
Autores principales: Payer, Lindsay M, Steranka, Jared P, Ardeljan, Daniel, Walker, JaNiece, Fitzgerald, Kathryn C, Calabresi, Peter A, Cooper, Thomas A, Burns, Kathleen H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326789/
https://www.ncbi.nlm.nih.gov/pubmed/30418605
http://dx.doi.org/10.1093/nar/gky1086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326789/
https://www.ncbi.nlm.nih.gov/pubmed/30418605
http://dx.doi.org/10.1093/nar/gky1086

Ejemplares similares