Cargando…

DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex

Cortical development is controlled by transcriptional programs, which are orchestrated by transcription factors. Yet, stable inheritance of spatio-temporal activity of factors influencing cell fate and localization in different layers is only partly understood. Here we find that deletion of Dot1l in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Franz, Henriette, Villarreal, Alejandro, Heidrich, Stefanie, Videm, Pavankumar, Kilpert, Fabian, Mestres, Ivan, Calegari, Federico, Backofen, Rolf, Manke, Thomas, Vogel, Tanja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326801/ https://www.ncbi.nlm.nih.gov/pubmed/30329130 http://dx.doi.org/10.1093/nar/gky953

Ejemplares similares

The transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and REST-binding sequences to maintain nephron progenitor identity
por: Li, Jun, et al.
Publicado: (2022)

Selective association between nucleosomes with identical DNA sequences
por: Nishikawa, Jun-ichi, et al.
Publicado: (2013)

Linker histone H1 modulates defense priming and immunity in plants
por: Sheikh, Arsheed H, et al.
Publicado: (2023)

PLZF limits enhancer activity during hematopoietic progenitor aging
por: Poplineau, Mathilde, et al.
Publicado: (2019)

Low RNA stability signifies increased post-transcriptional regulation of cell identity genes
por: Li, Yanqiang, et al.
Publicado: (2023)

PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression
por: Wan, Junhu, et al.
Publicado: (2015)

CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions
por: Feldmann, Angelika, et al.
Publicado: (2020)

Two Dot1 isoforms in Saccharomyces cerevisiae as a result of leaky scanning by the ribosome
por: Frederiks, Floor, et al.
Publicado: (2009)

Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism
por: van Welsem, Tibor, et al.
Publicado: (2018)

Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells
por: Zhao, Xin, et al.
Publicado: (2023)

Targeted DNA oxidation by LSD1–SMAD2/3 primes TGF-β1/ EMT genes for activation or repression
por: Pezone, Antonio, et al.
Publicado: (2020)

MOF-associated complexes ensure stem cell identity and Xist repression
por: Chelmicki, Tomasz, et al.
Publicado: (2014)

Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program
por: Aberle, Tim, et al.
Publicado: (2022)

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity
por: Freudenberg, Johannes M., et al.
Publicado: (2012)

Anti-inflammatory functions of the glucocorticoid receptor require DNA binding
por: Escoter-Torres, Laura, et al.
Publicado: (2020)

Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing
por: O’Geen, Henriette, et al.
Publicado: (2022)

PRMT1 loss sensitizes cells to PRMT5 inhibition
por: Gao, Guozhen, et al.
Publicado: (2019)

DNA residence time is a regulatory factor of transcription repression
por: Clauß, Karen, et al.
Publicado: (2017)

Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells
por: Tak, Yu Gyoung, et al.
Publicado: (2016)

Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor
por: Neault, Mathieu, et al.
Publicado: (2012)

dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression
por: O’Geen, Henriette, et al.
Publicado: (2017)

Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells
por: Eberle, Irina, et al.
Publicado: (2010)

DNA repair factor APLF acts as a H2A-H2B histone chaperone through binding its DNA interaction surface
por: Corbeski, Ivan, et al.
Publicado: (2018)

Epigenetic diversity of Kaposi’s sarcoma–associated herpesvirus
por: Darst, Russell P., et al.
Publicado: (2013)

Reverse crosstalk of TGFβ and PPARβ/δ signaling identified by transcriptional profiling
por: Stockert, Josefine, et al.
Publicado: (2011)

Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human
por: Birzele, Fabian, et al.
Publicado: (2011)

Artificial escape from XCI by DNA methylation editing of the CDKL5 gene
por: Halmai, Julian A N M, et al.
Publicado: (2020)

Genomic and proteomic analysis of transcription factor TFII-I reveals insight into the response to cellular stress
por: Fan, Alex Xiucheng, et al.
Publicado: (2014)

MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells
por: Sumida, Noriyuki, et al.
Publicado: (2020)

A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation
por: Shetty, Ankitha, et al.
Publicado: (2022)

Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner
por: Mishra, Vivek Kumar, et al.
Publicado: (2017)

Differential Methylation of H3K79 Reveals DOT1L Target Genes and Function in the Cerebellum In Vivo
por: Bovio, Patrick Piero, et al.
Publicado: (2018)

The transcription factor Sox5 modulates Sox10 function during melanocyte development
por: Stolt, C. Claus, et al.
Publicado: (2008)

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex
por: Thiaville, Michelle M., et al.
Publicado: (2008)

S-box and T-box riboswitches and antisense RNA control a sulfur metabolic operon of Clostridium acetobutylicum
por: André, Gaëlle, et al.
Publicado: (2008)

The CaMV transactivator/viroplasmin interferes with RDR6-dependent trans-acting and secondary siRNA pathways in Arabidopsis
por: Shivaprasad, Padubidri V., et al.
Publicado: (2008)

Expanded binding specificity of the human histone chaperone NASP
por: Wang, Huanyu, et al.
Publicado: (2008)

Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRγ
por: Song, Guisheng, et al.
Publicado: (2008)

Phosphorylation of the carboxy-terminal domain of histone H1: effects on secondary structure and DNA condensation
por: Roque, Alicia, et al.
Publicado: (2008)

Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk
por: Spatuzza, Carmen, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_k4f9jl597gl5qd0rib4i91v8fl