Genome-wide mapping of 8-oxo-7,8-dihydro-2′-deoxyguanosine reveals accumulation of oxidatively-generated damage at DNA replication origins within transcribed long genes of mammalian cells

8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is one of the major DNA modifications and a potent pre-mutagenic lesion prone to mispair with 2′-deoxyadenosine (dA). Several thousand residues of 8-oxodG are constitutively generated in the genome of mammalian cells, but their genomic distribution has n...

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Detalles Bibliográficos
Autores principales: Amente, Stefano, Di Palo, Giacomo, Scala, Giovanni, Castrignanò, Tiziana, Gorini, Francesca, Cocozza, Sergio, Moresano, Angela, Pucci, Piero, Ma, Bin, Stepanov, Irina, Lania, Luigi, Pelicci, Pier Giuseppe, Dellino, Gaetano Ivan, Majello, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326803/
https://www.ncbi.nlm.nih.gov/pubmed/30462294
http://dx.doi.org/10.1093/nar/gky1152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326803/
https://www.ncbi.nlm.nih.gov/pubmed/30462294
http://dx.doi.org/10.1093/nar/gky1152

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