Activation of the oncogenic transcription factor B-Myb via multisite phosphorylation and prolyl cis/trans isomerization

The oncogenic transcription factor B-Myb is an essential regulator of late cell cycle genes whose activation by phosphorylation is still poorly understood. We describe a stepwise phosphorylation mechanism of B-Myb, which involves sequential phosphorylations mediated by cyclin-dependent kinase (Cdk)...

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Detalles Bibliográficos
Autores principales: Werwein, Eugen, Cibis, Hannah, Hess, Daniel, Klempnauer, Karl-Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326806/
https://www.ncbi.nlm.nih.gov/pubmed/30321399
http://dx.doi.org/10.1093/nar/gky935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326806/
https://www.ncbi.nlm.nih.gov/pubmed/30321399
http://dx.doi.org/10.1093/nar/gky935

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