Cargando…

Resting cells rely on the DNA helicase component MCM2 to build cilia

Minichromosome maintenance (MCM) proteins facilitate replication by licensing origins and unwinding the DNA double strand. Interestingly, the number of MCM hexamers greatly exceeds the number of firing origins suggesting additional roles of MCMs. Here we show a hitherto unanticipated function of MCM...

Descripción completa

Detalles Bibliográficos
Autores principales:	Casar Tena, Teresa, Maerz, Lars D, Szafranski, Karol, Groth, Marco, Blätte, Tamara J, Donow, Cornelia, Matysik, Sabrina, Walther, Paul, Jeggo, Penelope A, Burkhalter, Martin D, Philipp, Melanie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326816/ https://www.ncbi.nlm.nih.gov/pubmed/30329080 http://dx.doi.org/10.1093/nar/gky945

Ejemplares similares

Specificity of MYB interactions relies on motifs in ordered and disordered contexts
por: Millard, Peter S, et al.
Publicado: (2019)

Genome-wide function of MCM-BP in Trypanosoma brucei DNA replication and transcription
por: Kim, Hee-Sook
Publicado: (2019)

The N-terminus of Spt16 anchors FACT to MCM2–7 for parental histone recycling
por: Wang, Xuezheng, et al.
Publicado: (2023)

Role of Cdc23/Mcm10 in generating the ribonucleotide imprint at the mat1 locus in fission yeast
por: Singh, Balveer, et al.
Publicado: (2019)

RNA helicase-dependent gene looping impacts messenger RNA processing
por: Terrone, Sophie, et al.
Publicado: (2022)

Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entry
por: Hayashi-Takanaka, Yoko, et al.
Publicado: (2021)

ATRX histone binding and helicase activities have distinct roles in neuronal differentiation
por: Bieluszewska, Anna, et al.
Publicado: (2022)

Recruitment of transcription factor ETS1 to activated accessible regions promotes the transcriptional program of cilia genes
por: Zhang, Donghui, et al.
Publicado: (2023)

Physiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons
por: Szafranski, Karol, et al.
Publicado: (2014)

The DEAD-box helicase Hlc regulates basal transcription and chromatin opening of stress-responsive genes
por: Jia, Ruirui, et al.
Publicado: (2022)

The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways
por: Samaan, Samaan, et al.
Publicado: (2014)

The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs
por: Nicklas, Sarah, et al.
Publicado: (2015)

The RNA helicase DDX17 controls the transcriptional activity of REST and the expression of proneural microRNAs in neuronal differentiation
por: Lambert, Marie-Pierre, et al.
Publicado: (2018)

A transient α-helical molecular recognition element in the disordered N-terminus of the Sgs1 helicase is critical for chromosome stability and binding of Top3/Rmi1
por: Kennedy, Jessica A., et al.
Publicado: (2013)

Characterization of the accessible genome in the human malaria parasite Plasmodium falciparum
por: Ruiz, José Luis, et al.
Publicado: (2018)

Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells
por: Morante-Palacios, Octavio, et al.
Publicado: (2022)

Linker histone H1 modulates defense priming and immunity in plants
por: Sheikh, Arsheed H, et al.
Publicado: (2023)

Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters
por: Carrera, Samantha, et al.
Publicado: (2021)

The transcription factor Sox5 modulates Sox10 function during melanocyte development
por: Stolt, C. Claus, et al.
Publicado: (2008)

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex
por: Thiaville, Michelle M., et al.
Publicado: (2008)

S-box and T-box riboswitches and antisense RNA control a sulfur metabolic operon of Clostridium acetobutylicum
por: André, Gaëlle, et al.
Publicado: (2008)

The CaMV transactivator/viroplasmin interferes with RDR6-dependent trans-acting and secondary siRNA pathways in Arabidopsis
por: Shivaprasad, Padubidri V., et al.
Publicado: (2008)

Expanded binding specificity of the human histone chaperone NASP
por: Wang, Huanyu, et al.
Publicado: (2008)

Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRγ
por: Song, Guisheng, et al.
Publicado: (2008)

Phosphorylation of the carboxy-terminal domain of histone H1: effects on secondary structure and DNA condensation
por: Roque, Alicia, et al.
Publicado: (2008)

Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk
por: Spatuzza, Carmen, et al.
Publicado: (2008)

Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
por: Ray, Sutapa, et al.
Publicado: (2008)

TAp73β and DNp73β activate the expression of the pro-survival caspase-2(S)
por: Toh, Wen Hong, et al.
Publicado: (2008)

The orphan receptor ERRα interferes with steroid signaling
por: Teyssier, Catherine, et al.
Publicado: (2008)

An intronic microRNA silences genes that are functionally antagonistic to its host gene
por: Barik, Sailen
Publicado: (2008)

Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex, cell type-specific landscape with novel regulatory elements
por: Taylor, Jennifer M., et al.
Publicado: (2008)

A high-throughput percentage-of-binding strategy to measure binding energies in DNA–protein interactions: application to genome-scale site discovery
por: Wang, Xiaohu, et al.
Publicado: (2008)

The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation
por: Stefanovsky, Victor Y., et al.
Publicado: (2008)

Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription
por: Wang, Wen-Ling, et al.
Publicado: (2008)

Context dependent function of APPb enhancer identified using enhancer trap-containing BACs as transgenes in zebrafish
por: Shakes, Leighcraft A., et al.
Publicado: (2008)

Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L
por: Jurkowska, Renata Z., et al.
Publicado: (2008)

Characterization of new regulatory elements within the Drosophila bithorax complex
por: Pérez-Lluch, Sílvia, et al.
Publicado: (2008)

Positional distribution of human transcription factor binding sites
por: Koudritsky, Mark, et al.
Publicado: (2008)

The 5′ end of two redundant sRNAs is involved in the regulation of multiple targets, including their own regulator
por: Guillier, Maude, et al.
Publicado: (2008)

Nonradioactive, ultrasensitive site-specific protein–protein photocrosslinking: interactions of α-helix 2 of TATA-binding protein with general transcription factor TFIIA and transcriptional repressor NC2
por: Kim, Younggyu, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ectvdjf1vucrcdmlem5gh2se6t