Kinetic pathways of topology simplification by Type-II topoisomerases in knotted supercoiled DNA

The topological state of covalently closed, double-stranded DNA is defined by the knot type [Formula: see text] and the linking-number difference [Formula: see text] relative to unknotted relaxed DNA. DNA topoisomerases are essential enzymes that control the topology of DNA in all cells. In particul...

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Detalles Bibliográficos
Autores principales: Ziraldo, Riccardo, Hanke, Andreas, Levene, Stephen D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326819/
https://www.ncbi.nlm.nih.gov/pubmed/30476194
http://dx.doi.org/10.1093/nar/gky1174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326819/
https://www.ncbi.nlm.nih.gov/pubmed/30476194
http://dx.doi.org/10.1093/nar/gky1174

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