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Kinetic pathways of topology simplification by Type-II topoisomerases in knotted supercoiled DNA
The topological state of covalently closed, double-stranded DNA is defined by the knot type [Formula: see text] and the linking-number difference [Formula: see text] relative to unknotted relaxed DNA. DNA topoisomerases are essential enzymes that control the topology of DNA in all cells. In particul...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326819/ https://www.ncbi.nlm.nih.gov/pubmed/30476194 http://dx.doi.org/10.1093/nar/gky1174 |