IGF2BP1 promotes SRF-dependent transcription in cancer in a m(6)A- and miRNA-dependent manner

The oncofetal mRNA-binding protein IGF2BP1 and the transcriptional regulator SRF modulate gene expression in cancer. In cancer cells, we demonstrate that IGF2BP1 promotes the expression of SRF in a conserved and N(6)-methyladenosine (m(6)A)-dependent manner by impairing the miRNA-directed decay of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Müller, Simon, Glaß, Markus, Singh, Anurag K, Haase, Jacob, Bley, Nadine, Fuchs, Tommy, Lederer, Marcell, Dahl, Andreas, Huang, Huilin, Chen, Jianjun, Posern, Guido, Hüttelmaier, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326824/
https://www.ncbi.nlm.nih.gov/pubmed/30371874
http://dx.doi.org/10.1093/nar/gky1012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326824/
https://www.ncbi.nlm.nih.gov/pubmed/30371874
http://dx.doi.org/10.1093/nar/gky1012

Ejemplares similares