Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice

Growth factor independent 1 (Gfi1) controls myeloid differentiation by regulating gene expression and limits the activation of p53 by facilitating its de-methylation at Lysine 372. In human myeloid leukemia, low GFI1 levels correlate with an inferior prognosis. Here, we show that knockdown (KD) of G...

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Detalles Bibliográficos
Autores principales: Fraszczak, Jennifer, Vadnais, Charles, Rashkovan, Marissa, Ross, Julie, Beauchemin, Hugues, Chen, Riyan, Grapton, Damien, Khandanpour, Cyrus, Möröy, Tarik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326955/
https://www.ncbi.nlm.nih.gov/pubmed/29925903
http://dx.doi.org/10.1038/s41375-018-0166-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326955/
https://www.ncbi.nlm.nih.gov/pubmed/29925903
http://dx.doi.org/10.1038/s41375-018-0166-1

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