BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

Loss of BRCA2 affects genome stability and is deleterious for cellular survival. Using a genome-wide genetic screen in near-haploid KBM-7 cells, we show that tumor necrosis factor-alpha (TNFα) signaling is a determinant of cell survival upon BRCA2 inactivation. Specifically, inactivation of the TNF...

Descripción completa

Detalles Bibliográficos
Autores principales: Heijink, Anne Margriet, Talens, Francien, Jae, Lucas T., van Gijn, Stephanie E., Fehrmann, Rudolf S. N., Brummelkamp, Thijn R., van Vugt, Marcel A. T. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327059/
https://www.ncbi.nlm.nih.gov/pubmed/30626869
http://dx.doi.org/10.1038/s41467-018-07927-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327059/
https://www.ncbi.nlm.nih.gov/pubmed/30626869
http://dx.doi.org/10.1038/s41467-018-07927-y

Ejemplares similares