Optimizing Antitumor Efficacy and Adverse Effects of Pegylated Liposomal Doxorubicin by Scheduled Plasmapheresis: Impact of Timing and Dosing

BACKGROUND: Nanoscale drug delivery systems accumulate in solid tumors preferentially by the enhanced permeation and retention effect (EPR-effect). Nevertheless, only a miniscule fraction of a given dosage reaches the tumor, while >90% of the given drug ends up in otherwise healthy tissues, lead-...

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Detalles Bibliográficos
Autores principales: Ngoune, Romeo, Contini, Christine, Hoffmann, Michael M., von Elverfeldt, Dominik, Winkler, Karl, Pütz, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327121/
https://www.ncbi.nlm.nih.gov/pubmed/29779479
http://dx.doi.org/10.2174/1567201815666180518125839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327121/
https://www.ncbi.nlm.nih.gov/pubmed/29779479
http://dx.doi.org/10.2174/1567201815666180518125839

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