Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

BACKGROUND: TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer’s disease (AD). Soluble TREM2 (sTREM2) resulting from shedding of the TREM2 ectodomain can be detected...

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Detalles Bibliográficos
Autores principales: Suárez-Calvet, Marc, Morenas-Rodríguez, Estrella, Kleinberger, Gernot, Schlepckow, Kai, Caballero, Miguel Ángel Araque, Franzmeier, Nicolai, Capell, Anja, Fellerer, Katrin, Nuscher, Brigitte, Eren, Erden, Levin, Johannes, Deming, Yuetiva, Piccio, Laura, Karch, Celeste M., Cruchaga, Carlos, Shaw, Leslie M., Trojanowski, John Q., Weiner, Michael, Ewers, Michael, Haass, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327425/
https://www.ncbi.nlm.nih.gov/pubmed/30630532
http://dx.doi.org/10.1186/s13024-018-0301-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327425/
https://www.ncbi.nlm.nih.gov/pubmed/30630532
http://dx.doi.org/10.1186/s13024-018-0301-5

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